prikaz prve stranice dokumenta The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation
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Scientific paper - Review paper
The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation
International Journal of Molecular Sciences, 24 (2023), 3; 2959. https://doi.org/10.3390/ijms24032959
Poljšak, Borut; Kovač, Vito; Špalj, Stjepan; Milisav, Irina

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Poljšak, B., Kovač, V., Špalj, S. & Milisav, I. (2023). The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation. International Journal of Molecular Sciences, 24. (3). doi: 10.3390/ijms24032959

Poljšak, Borut, et al. "The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation." International Journal of Molecular Sciences, vol. 24, no. 3, 2023. https://doi.org/10.3390/ijms24032959

Poljšak, Borut, Vito Kovač, Stjepan Špalj and Irina Milisav. "The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation." International Journal of Molecular Sciences 24, no. 3 (2023). https://doi.org/10.3390/ijms24032959

Poljšak, B., et al. (2023) 'The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation', International Journal of Molecular Sciences, 24(3). doi: 10.3390/ijms24032959

Poljšak B, Kovač V, Špalj S, Milisav I. The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation. International Journal of Molecular Sciences [Internet]. 2023 February 03 [cited 2024 May 17];24(3). doi: 10.3390/ijms24032959

B. Poljšak, V. Kovač, S. Špalj and I. Milisav, "The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation", International Journal of Molecular Sciences, vol. 24, no. 3, February 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:271:479593. [Accessed: 17 May 2024]

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Metadata
Title (english)The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation
AuthorBorut Poljšak
AuthorVito Kovač
AuthorStjepan Špalj
AuthorIrina Milisav
Author's institutionUniversity of Rijeka
(Faculty of Dental Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Abstract (english)
The molecule NAD+ is a coenzyme for enzymes catalyzing cellular redox reactions in several metabolic pathways, encompassing glycolysis, TCA cycle, and oxidative phosphorylation, and is a substrate for NAD+-dependent enzymes. In addition to a hydride and electron transfer in redox reactions, NAD+ is a substrate for sirtuins and poly(adenosine diphosphate–ribose) polymerases and even moderate decreases in its cellular concentrations modify signaling of NAD+-consuming enzymes. Age-related reduction in cellular NAD+ concentrations results in metabolic and aging-associated disorders, while the consequences of increased NAD+ production or decreased degradation seem beneficial. This article reviews the NAD+ molecule in the development of aging and the prevention of chronic age-related diseases and discusses the strategies of NAD+ modulation for healthy aging and longevity.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 24, no. 3, 2959
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24032959
URN:NBNurn:nbn:hr:271:479593
Publication2023-02-03
Document URLhttps://www.mdpi.com/1422-0067/24/3/2959
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-05-17 11:14:35