The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation

Poljšak, Borut; Kovač, Vito; Špalj, Stjepan; Milisav, Irina

doi:10.3390/ijms24032959

prikaz prve stranice dokumenta The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation

Scientific paper - Review paper

The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation

International Journal of Molecular Sciences, 24 (2023), 3; 2959. https://doi.org/10.3390/ijms24032959

Poljšak, Borut; Kovač, Vito; Špalj, Stjepan; Milisav, Irina

Cite this document

APA 6th Edition

Poljšak, B., Kovač, V., Špalj, S. & Milisav, I. (2023). The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation. International Journal of Molecular Sciences, 24. (3). doi: 10.3390/ijms24032959

MLA 8th Edition

Poljšak, Borut, et al. "The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation." International Journal of Molecular Sciences, vol. 24, no. 3, 2023. https://doi.org/10.3390/ijms24032959

Chicago 17th Edition

Poljšak, Borut, Vito Kovač, Stjepan Špalj and Irina Milisav. "The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation." International Journal of Molecular Sciences 24, no. 3 (2023). https://doi.org/10.3390/ijms24032959

Harvard

Poljšak, B., et al. (2023) 'The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation', International Journal of Molecular Sciences, 24(3). doi: 10.3390/ijms24032959

Vancouver

Poljšak B, Kovač V, Špalj S, Milisav I. The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation. International Journal of Molecular Sciences [Internet]. 2023 February 03 [cited 2024 December 21];24(3). doi: 10.3390/ijms24032959

IEEE

B. Poljšak, V. Kovač, S. Špalj and I. Milisav, "The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation", International Journal of Molecular Sciences, vol. 24, no. 3, February 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:271:479593. [Accessed: 21 December 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:271:479593

Please login to the repository to save this object to your list.

Metadata

Title (english)	The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation
Author	Borut Poljšak
Author	Vito Kovač
Author	Stjepan Špalj
Author	Irina Milisav
Author's institution	University of Rijeka (Faculty of Dental Medicine)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Dental Medicine
Abstract (english)	The molecule NAD+ is a coenzyme for enzymes catalyzing cellular redox reactions in several metabolic pathways, encompassing glycolysis, TCA cycle, and oxidative phosphorylation, and is a substrate for NAD+-dependent enzymes. In addition to a hydride and electron transfer in redox reactions, NAD+ is a substrate for sirtuins and poly(adenosine diphosphate–ribose) polymerases and even moderate decreases in its cellular concentrations modify signaling of NAD+-consuming enzymes. Age-related reduction in cellular NAD+ concentrations results in metabolic and aging-associated disorders, while the consequences of increased NAD+ production or decreased degradation seem beneficial. This article reviews the NAD+ molecule in the development of aging and the prevention of chronic age-related diseases and discusses the strategies of NAD+ modulation for healthy aging and longevity.
Keywords (english)
Language	english
Publication type	Scientific paper - Review paper
Publication status	Published
Peer review	Peer review - international
Publication version	Published version
Journal title	International Journal of Molecular Sciences
Numbering	vol. 24, no. 3, 2959
e-ISSN	1422-0067
DOI	https://doi.org/10.3390/ijms24032959
URN:NBN	urn:nbn:hr:271:479593
Publication	2023-02-03
Document URL	https://www.mdpi.com/1422-0067/24/3/2959
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2023-05-17 11:14:35