The success of the implementation of endodontic treatment of pulp and periapical diseases of the tooth lies in the knowledge of the pathogenesis of the disease, the morphology of the endodontic space of the tooth, and the materials and instruments. The concept of minimally invasive endodontics is aimed at a conservative approach to the preservation of hard dental tissues, especially dentin, during root canal instrumentation to preserve the structural integrity of the teeth, improve the longevity of the teeth and provide the patient with the greatest possible comfort of therapeutic procedures. In this regard, the development of the concept went in the direction of the introduction of conservative diagnostic and therapeutic techniques that include the use of imaging techniques of three-dimensional representations of anatomical structures, the use of magnifying glasses and microscopes, and computer programs in the planning of guided endodontic therapy. An important role is also played by rotary endodontic instruments made of nickel-titanium alloys by thermo-mechanical processing procedures. Their biocompatibility, resistance to corrosion and material fatigue, cutting efficiency, superelasticity and shape memory property have brought them to the very top of endodontic instruments. Adequate knowledge of the characteristics of individual generations of rotary NiTi instruments and work techniques is important to be able to make a valid decision about which instruments to use in which case. Necessarily the best and latest instrument does not mean the best solution. In this paper, a more detailed overview of the characteristics and mode of operation of the SAF instrument (Self adjusting file) and the instruments of the XP-Endo system in terms of their capabilities for minimally invasive three-dimensional instrumentation of root canals is presented.