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Scientific paper - Original scientific paper
P2Y2 Receptors Mediate Masseter Muscle Mechanical Hypersensitivity in Rats
Journal of Pain Research, Volume 13 (2020); 1323-1333. https://doi.org/10.2147/JPR.S239831
Tariba Knežević, Petra; Vukman, Robert; Uhač, Mia; Illeš, Davor; Kovačević Pavičić, Daniela; Simonić-Kocijan, Sunčana

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Tariba Knežević, P., Vukman, R., Uhač, M., Illeš, D., Kovačević Pavičić, D. & Simonić Kocijan, S. (2020). P2Y2 Receptors Mediate Masseter Muscle Mechanical Hypersensitivity in Rats. Journal of Pain Research, Volume 13., 1323-1333. doi: 10.2147/JPR.S239831

Tariba Knežević, Petra, et al. "P2Y2 Receptors Mediate Masseter Muscle Mechanical Hypersensitivity in Rats." Journal of Pain Research, vol. Volume 13, 2020, pp. 1323-1333. https://doi.org/10.2147/JPR.S239831

Tariba Knežević, Petra, Robert Vukman, Mia Uhač, Davor Illeš, Daniela Kovačević Pavičić and Sunčana Simonić Kocijan. "P2Y2 Receptors Mediate Masseter Muscle Mechanical Hypersensitivity in Rats." Journal of Pain Research Volume 13 (2020): 1323-1333. https://doi.org/10.2147/JPR.S239831

Tariba Knežević, P., et al. (2020) 'P2Y2 Receptors Mediate Masseter Muscle Mechanical Hypersensitivity in Rats', Journal of Pain Research, Volume 13, pp. 1323-1333. doi: 10.2147/JPR.S239831

Tariba Knežević P, Vukman R, Uhač M, Illeš D, Kovačević Pavičić D, Simonić Kocijan S. P2Y2 Receptors Mediate Masseter Muscle Mechanical Hypersensitivity in Rats. Journal of Pain Research [Internet]. 2020 June [cited 2025 March 09];Volume 13:1323-1333. doi: 10.2147/JPR.S239831

P. Tariba Knežević, R. Vukman, M. Uhač, D. Illeš, D. Kovačević Pavičić and S. Simonić Kocijan, "P2Y2 Receptors Mediate Masseter Muscle Mechanical Hypersensitivity in Rats", Journal of Pain Research, vol. Volume 13, pp. 1323-1333, June 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:271:451566. [Accessed: 09 March 2025]

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Metadata
Title (english)P2Y2 Receptors Mediate Masseter Muscle Mechanical Hypersensitivity in Rats
AuthorPetra Tariba Knežević
AuthorRobert Vukman
AuthorMia Uhač
AuthorDavor Illeš
AuthorDaniela Kovačević Pavičić
AuthorSunčana Simonić-Kocijan
Author's institutionUniversity of Rijeka
(Faculty of Dental Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Prosthetic Dentistry
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Orthodontics
Abstract (english)
Purpose: P2Y2 receptors (P2Y2Rs) are among the various receptors that play an important role in nociception. The goal of this research was to investigate possible P2Y2R expression changes in the trigeminal ganglion (TRG) in bilateral masseter muscle (MM) hypersensitivity following unilateral MM inflammation. The impact of unilateral intramasseteric administration of P2Y2R antagonist on bilateral MM hypersensitivity was also explored. Materials and methods: Bilateral MM hypersensitivity was... More provoked by unilateral intramasseteric injection of complete Freund's adjuvant (CFA). The head withdrawal threshold (HWT) was assessed bilaterally 4 days later. Bilateral TRG and MM isolation were followed, and quantitative real-time polymerase chain reaction (qRT-PCR) and histopathological analysis were carried out on these tissues, respectively. The involvement of P2Y2Rs in nocifensive behavior was evaluated by administering two doses of P2Y2R antagonist AR-C118925 (0.2 or 1 mg/100 μL) in inflamed MM 4 days post-CFA administration. Bilateral HWT was assessed at different time points following antagonist injection. Results: qRT-PCR analysis demonstrated P2Y2R up-regulation in TRG ipsilateral to the site of CFA administration. Compared to the controls, both doses of AR-C118925 injected ipsilateral to the TRG increased the bilateral HWT at 30, 60, 90, and 120 minutes after antagonist administration. Conclusion: The findings suggest that P2Y2Rs may affect MM inflammatory hypersensitivity owing to its up-regulation in the TRG in MM inflammatory pain states. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Pain Research
Numberingvol. Volume 13, pp. 1323-1333
e-ISSN1178-7090
DOIhttps://doi.org/10.2147/JPR.S239831
URN:NBNurn:nbn:hr:271:451566
Publication2020-06
Document URLhttps://www.dovepress.com/p2y2-receptors-mediate-masseter-muscle-mechanical-hypersensitivity-in--peer-reviewed-article-JPR
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2023-01-19 09:39:40
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