Caries is one of the most common chronic infectious diseases affecting people around the world. It affects the hard tooth tissue and it presents an unfavorable result of dynamic changes in the process of demineralization and remineralization, ie it occurs when demineralization prevailed. Demineralization is the dissolution of hard tooth tissue, and remineralization is the restoration of components lost during demineralization. Preventive and interceptive procedures are important to prevent the formation or stop the progression of the initial carious lesion. They refer to the remineralization of dental tissue, ie fluoridation in the narrow sense. Fluorides have proven to be a very effective tool in caries prevention and can be applied systemically or topically. Systemic use is increasingly being abandoned today due to the risk of dental fluorosis, and includes the consumption of fluoridated water, salt or milk, and the intake of fluoride tablets. Topical fluoridation can be carried out in the form of toothpastes and mouthwashes, in the form of gels, varnishes, solutions, mouthwashes, chewing gum, fluoride release devices and restorative materials capable of releasing fluoride. According to the chemical composition of fluorine compounds in preparations for topical fluoridation, they are divided into inorganic and organic. Inorganic compounds are sodium fluoride, sodium monofluorophosphate, tin fluoride, acidified fluorine preparations and titanium tetrafluoride, and organic are amine fluoride and SDF. In addition to fluorine preparations for remineralization, agents based on calcium phosphate and hydroxyapatite are also used. Calcium phosphate compounds are ACP, CPP-ACP and bioactive glass. SDF has been shown to be the best agent in caries prevention, followed by NaF agents and then CPP-ACP containing agents.