CAD/CAM technology was introduced in dentistry in the 1970s, and its main components are a scanner, a computer program and a milling machine. Together, they represent a modern CAD/CAM unit, which has led to the improvement of the process of manufacturing prosthetic restorations, simultaneously increasing both quality and speed. The disadvantage is the high price, as well as the time required to master the work technique. Prosthetic restorations can be made using digital technology directly in office (chairside), indirectly in the dental laboratory (in lab system) or in production centers. Depending on the possibility of sharing data, systems can be open or closed. There is a wide selection of different materials for CAD/CAM processing on the market and their properties are constantly being improved. Special emphasis is placed on ceramic systems, since their aesthetic properties best imitate the characteristics of natural teeth. Current ceramic materials include oxide ceramics (mainly zirconium oxide ceramics), various types of glass ceramics and hybrid ceramics, such as nanoceramics and PICN, which represent a combination of ceramic and composite materials. In addition to ceramic materials, resin composite blocks and PMMA are also available for machining. It is of great importance that the clinician is well acquainted with the features of individual materials, their indications and limitations in practice, in order to be able to choose the correct material for a specific clinical situation and handle it properly. In this way, the high aesthetic standards imposed by modern dental medicine can be met, along with the indispensable establishment of function and preservation of the health of the stomatognathic system.