prikaz prve stranice dokumenta Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival
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Scientific paper - Original scientific paper
Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival
Current Issues in Molecular Biology, 45 (2023), 4; 2757-2766. https://doi.org/10.3390/cimb45040180
Zulijani, Ana; Milardović, Ana; Kovač, Zoran; Perić, Berislav; Jakovac, Hrvoje

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Zulijani, A., Milardović, A., Kovač, Z., Perić, B. & Jakovac, H. (2023). Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival. Current Issues in Molecular Biology, 45. (4), 2757-2766. doi: 10.3390/cimb45040180

Zulijani, Ana, et al. "Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival." Current Issues in Molecular Biology, vol. 45, no. 4, 2023, pp. 2757-2766. https://doi.org/10.3390/cimb45040180

Zulijani, Ana, Ana Milardović, Zoran Kovač, Berislav Perić and Hrvoje Jakovac. "Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival." Current Issues in Molecular Biology 45, no. 4 (2023): 2757-2766. https://doi.org/10.3390/cimb45040180

Zulijani, A., et al. (2023) 'Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival', Current Issues in Molecular Biology, 45(4), pp. 2757-2766. doi: 10.3390/cimb45040180

Zulijani A, Milardović A, Kovač Z, Perić B, Jakovac H. Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival. Current Issues in Molecular Biology [Internet]. 2023 March 24 [cited 2024 December 22];45(4):2757-2766. doi: 10.3390/cimb45040180

A. Zulijani, A. Milardović, Z. Kovač, B. Perić and H. Jakovac, "Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival", Current Issues in Molecular Biology, vol. 45, no. 4, pp. 2757-2766, March 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:271:544942. [Accessed: 22 December 2024]

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Metadata
Title (english)Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival
AuthorAna Zulijani
AuthorAna Milardović
AuthorZoran Kovač
AuthorBerislav Perić
AuthorHrvoje Jakovac
Author's institutionUniversity of Rijeka
(Faculty of Dental Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Abstract (english)
Megalin (LRP2) is a rapidly recycling multiligand endocytic receptor primarily expressed in polarized epithelial cells. Although megalin might be involved in tumor growth and invasiveness through several mechanisms, its role has been understudied in the field of molecular oncology so far. The present study aimed to evaluate the impact of megalin expression in oral squamous cell carcinoma (OSCC) on disease progression. Megalin expression was evaluated immunohistochemically in 63 OSCC specimens. Data obtained were retrospectively compared with patient clinicopathological features and their survival. The proportion of megalin-expressing cells in the primary OSCC tissue was significantly associated with metastatic spreading to lymph nodes, vascular invasion and lower overall survival rate. Results obtained by the study suggest that megalin can be considered as a novel molecule involved in OSCC pathogenesis, but also useful as a potential biomarker for cancer progression.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCurrent Issues in Molecular Biology
Numberingvol. 45, no. 4, pp. 2757-2766
e-ISSN1467-3045
DOIhttps://doi.org/10.3390/cimb45040180
URN:NBNurn:nbn:hr:271:544942
Publication2023-03-24
Document URLhttps://www.mdpi.com/1467-3045/45/4/180
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2023-05-17 11:02:23