prikaz prve stranice dokumenta Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival
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Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival
Current Issues in Molecular Biology, 45 (2023), 4; 2757-2766. https://doi.org/10.3390/cimb45040180
Zulijani, Ana; Milardović, Ana; Kovač, Zoran; Perić, Berislav; Jakovac, Hrvoje

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Zulijani, A., Milardović, A., Kovač, Z., Perić, B. i Jakovac, H. (2023). Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival. Current Issues in Molecular Biology, 45. (4), 2757-2766. doi: 10.3390/cimb45040180

Zulijani, Ana, et al. "Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival." Current Issues in Molecular Biology, vol. 45, br. 4, 2023, str. 2757-2766. https://doi.org/10.3390/cimb45040180

Zulijani, Ana, Ana Milardović, Zoran Kovač, Berislav Perić i Hrvoje Jakovac. "Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival." Current Issues in Molecular Biology 45, br. 4 (2023): 2757-2766. https://doi.org/10.3390/cimb45040180

Zulijani, A., et al. (2023) 'Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival', Current Issues in Molecular Biology, 45(4), str. 2757-2766. doi: 10.3390/cimb45040180

Zulijani A, Milardović A, Kovač Z, Perić B, Jakovac H. Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival. Current Issues in Molecular Biology [Internet]. 24.03.2023. [pristupljeno 22.12.2024.];45(4):2757-2766. doi: 10.3390/cimb45040180

A. Zulijani, A. Milardović, Z. Kovač, B. Perić i H. Jakovac, "Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival", Current Issues in Molecular Biology, vol. 45, br. 4, str. 2757-2766, Ožujak 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:271:544942. [Citirano: 22.12.2024.]

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Naslov (engleski)Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated with the Presence of Lymph Node Metastases, Vascular Invasion, and Lower Overall Survival
AutorAna Zulijani
AutorAna Milardović
AutorZoran Kovač
AutorBerislav Perić
AutorHrvoje Jakovac
Autorova ustanovaSveučilište u Rijeci
(Fakultet dentalne medicine)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Dentalna medicina
Sažetak (engleski)
Megalin (LRP2) is a rapidly recycling multiligand endocytic receptor primarily expressed in polarized epithelial cells. Although megalin might be involved in tumor growth and invasiveness through several mechanisms, its role has been understudied in the field of molecular oncology so far. The present study aimed to evaluate the impact of megalin expression in oral squamous cell carcinoma (OSCC) on disease progression. Megalin expression was evaluated immunohistochemically in 63 OSCC specimens. Data obtained were retrospectively compared with patient clinicopathological features and their survival. The proportion of megalin-expressing cells in the primary OSCC tissue was significantly associated with metastatic spreading to lymph nodes, vascular invasion and lower overall survival rate. Results obtained by the study suggest that megalin can be considered as a novel molecule involved in OSCC pathogenesis, but also useful as a potential biomarker for cancer progression.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCurrent Issues in Molecular Biology
Brojčani podacivol. 45, br. 4, str. 2757-2766
e-ISSN1467-3045
DOIhttps://doi.org/10.3390/cimb45040180
URN:NBNurn:nbn:hr:271:544942
Datum objave publikacije2023-03-24
URL dokumentahttps://www.mdpi.com/1467-3045/45/4/180
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2023-05-17 11:02:23