Antiseptics are chemicals that, when applied topically to intact skin, mucous membranes or wounds, partially or completely reduce the population of living microorganisms in these tissues. They are intended to act on the skin and mucous membranes. Their action on microorganisms is bacteriostatic, bactericidal, fungicidal and virucidal, which often depends on the concentration of antiseptics. The effectiveness of antiseptics and disinfectants depends on the time of action, temperature, type and concentration of the active ingredient, the presence of organic matter, and the type and amount of microbiological load. The mechanisms of action of antiseptics are denaturation of cellular proteins; oxidation of essential sulfhydryl groups of enzymes; alkylation of the amino, carboxyl and hydroxyl groups; nucleic acid damage and action on the cell membrane. In dentistry, antiseptics for the mucosa and antiseptics for the tooth are used. By localization, they can be applied to the entire mucosa, in the area of the gingiva and gingival sulcus and pockets, and in the dental alveolus during tooth extraction. Tooth antiseptics are used in higher concentrations than for mucous membranes. They are applied to or into the tooth. Antiseptics are divided into groups: alcohols, aldehydes, phenol and phenol derivatives, halogens and their compounds, oxidizing agents, surfactants. In pediatric dentistry, the use of antiseptics is part of preventive and therapeutic procedures in infectious diseases of the oral cavity. In the prevention of gingivitis and caries, antiseptics in the form of mouthwash solutions are mainly used. When administering the product, attention should be paid to the child's age and the ability to spit out the antiseptic after use. The use of antiseptic solutions is used to reduce the number of microorganisms before and after oral surgery in the oral cavity. Antiseptic therapy is also used as an adjunct to mechanical cleansing in the treatment of periodontal tissue diseases such as gingivitis and periodontitis. In pediatric dentistry, antiseptics play a significant role as part of endodontic therapy where they are used as part of vital and devitalization pulpotomy and pulpectomy. Antiseptics are used as irrigation agents in the chemical treatment of the root canals of deciduous and permanent teeth, and as intracanal inserts that are placed between two visits. After chemical and mechanical treatment, pastes are used to fill the root canals of deciduous teeth, which also Proper selection of antiseptics is a prerequisite for successful treatment and therefore it is important to consider the spectrum of its antimicrobial action, latency, residual effects, possible interference with the presence of organic material with antiseptic activity, compatibility with other antiseptics and side effects and cost. The effectiveness of antiseptics is also affected by the concentration, duration of action and temperature of the agent.